We did not find any significant other long-term complications, though the prevalence of Crohn's disease was higher and the prevalence of ulcerative colitis was lower after appendectomy than in controls. Mortality was low after appendectomy.Īppendectomy had a low prevalence of long-term surgical complications. Pregnancy rates increased after appendicitis compared with controls in most studies. No clear pattern was found regarding most of the examined cancers in appendectomy groups compared with background populations. The opposite pattern was found regarding Crohn's disease with a pooled estimate of 0.20% prevalence in the appendectomy group and 0.12% in controls. Ulcerative colitis had a pooled estimate of 0.15% prevalence in the appendectomy group and 0.19% in controls. Regarding incisional hernia, we found a pooled estimate of 0.7% prevalence within a follow-up period of 6.5 (range, 1.9-10) years.
The pooled estimate of the ileus prevalence was 1.0% over a follow-up period of 4.6 (range, 0.5-15) years. The surgical outcomes were ileus and incisional hernia other outcomes were inflammatory bowel disease, cancer, fertility, and mortality.
The databases PubMed and EMBASE were searched for original reports on appendectomy with n ≥ 500 and follow-up >30 days. A protocol was registered on PROSPERO (CRD42017064662). This systematic review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Our aim was to systematically review the long-term complications of appendectomy for acute appendicitis.
Appendectomy is a common surgical procedure, but no overview of the long-term consequences exists.
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